Tomas Murphy and Sidra Ilyas delivered a great morning report today about Valproate intoxication, here are the educational highlights from today’s case:
- GI decontamination (activated charcoal) in acute overdose
- Supportive care for hypotension and respiratory depression if present (IV fluids, vasopressors, mechanical ventilation, benzodiazepines in case of seizures….)
- Carnitine for valproate toxicity associated with hyperammonemia, coma, lethargy or hepatic dysfunction. Dose: 100 mg /kg IV over 30 minutes, followed by 50 mg/kg IV every 8 hrs
A nice differential for toxidromes was discussed by Tomas at the end, check out the presentation for more info!