Wayne State University
Detroit Medical Center
Internal Medicine Residency Program

Research and Scholarly Activity

Our Internal Medicine Residency Program is committed to fostering a robust culture of research and scholarly activity. Residents are encouraged to engage in innovative research projects, quality improvement initiatives, and evidence-based medicine to advance clinical care and medical knowledge. Residents in our program have access to experienced faculty mentors and resources, with opportunities to engage in research across various fields, including cardiology, gastroenterology, hematology, oncology, infectious disease, rheumatology, nephrology, endocrinology, behavioral medicine, and health equity.

Our program provides dedicated annual didactics on research and quality improvement, led by chief medical residents, to guide residents and interns through every step of the research process. These sessions cover topics such as starting a research project, formulating research questions, conducting literature searches, data collection, collaborating with statisticians, and academic writing. We also offer a mandatory lecture on the Institutional Review Board (IRB) process, delivered by the Associate Chair of Research for the Department of Medicine. This session provides a comprehensive overview of the IRB process, from project inception to approval. Residents are strongly encouraged to submit their research to local and national conferences and to actively participate in presenting their work at these events.

The faculty at Wayne State University provide dedicated mentorship to residents, guiding them through research projects and fostering their scholarly growth. Residents collaborate closely with faculty members to pursue innovative and impactful research. The Wayne State University School of Medicine, recognized by the Carnegie Foundation for its excellence in research and community engagement, is a leader in medical innovation. Notable achievements include:

  • Developing AZT, the first FDA-approved drug to treat AIDS.
  • Performing the first use of a mechanical heart pump in open-heart surgery.
  • Pioneering optogenetic strategies to restore vision.
  • Creating a cost-effective screening method to identify expectant mothers at risk of preterm birth and reducing preterm birth risk by 40%.

Renowned for its groundbreaking biomedical research, the Wayne State University School of Medicine ranks among Michigan’s top medical research institutions. Faculty, residents and students work in interdisciplinary teams across various settings to develop advanced techniques, technologies, and processes that improve patient care. In the 2023 fiscal year, the School of Medicine received over $183 million in research funding, highlighting its ongoing commitment to scientific discovery and innovation.

Here are some examples of recent scholarly activities by residents in our program:

Peer Reviewed Publications:

  1. Koussa S, Majagi A, Wang K, Devara A. Ludwig’s angina, anterior neck abscess and cavernous venous thrombosis following third molar extraction. BMJ Case Rep. 2023;16(9):e255938. PMID: 37669817.
  2. Bahar AR, Mishra T, Bahar Y, Othman M, Afonso L. Aortic valve vegetation due to nonbacterial thrombotic endocarditis in a patient with antiphospholipid antibody syndrome. CASE. 2024. PMID: 39221022. PMCID: PMC11364878.
  3. Kang WS, Zong Y, Patel D, Mishra T, Afonso L. Case: An unusual etiology of severe right heart failure deserving of wider recognition. J Am Coll Cardiol Case Rep. 2024;29(5):102222.
  4. Fatima AS, Imran N, Yaseen O, Alrawi O. Salt-losing nephropathy associated with supraventricular arrhythmia. BMJ Case Rep. 2024;17(7):e260718. doi:10.1136/bcr-2024-260718. PMID: 38977315.
  5. Bahar AR, Bahar Y, Alrayyashi M, Alraies MC. In-hospital outcomes of patients with acute respiratory distress syndrome treated with extracorporeal membrane oxygenation. Cureus. 2024;16(9):e68745.
  6. Shatila M, Zhang HC, Shirwaikar Thomas A, et al. Systematic review of immune checkpoint inhibitor-related gastrointestinal, hepatobiliary, and pancreatic adverse events. J Immunother Cancer. 2024;12(11):e009742. Published 2024 Nov 14. doi:10.1136/jitc-2024-009742.
  7. Sharma A, Sharma A, Soubani AO. Epidemiology and outcomes of CAR-T cell therapy recipients with septic shock in the United States. Hematol Oncol Stem Cell Ther. 2024; Published February 2024. doi:10.4103/hemoncstem.HEMONCSTEM-D-24-00031.
  8. Bahar AR, Kaur P, Singh M, Cardozo S. Inverted left atrial appendage developing after mitral valve replacement surgery. Cardiovasc Revasc Med: Interesting Cases. 2024; Published. Pages 100046.
  9. Shatila M, Wang Y. Response. Gastrointest Endosc. 2024;100(2):349-350. doi:10.1016/j.gie.2024.03.029.
  10. Kurtz D, Sharma A, Sharma A, Soubani AO. Epidemiology and outcomes of hospitalized chimeric antigen receptor T-cell (CAR-T) therapy patients who developed acute respiratory failure. J Intensive Care Med. 2023; Published December 2023. doi:10.1177/08850666241253537.
  11. Dwivedi R, Goyal P, Jain R, Sharma A, Dwivedi P, Singh P, Singh K. Burden and patterns of disease among tribals of South West Rajasthan. J Fam Med Prim Care. 2024; Accepted/In-Press.
  12. Bahar AR, Khanal R, Alraies MC. Assessing the efficacy of RADPAD protection drape in reducing radiation exposure to operators in the cardiac catheterization laboratory: A systematic review and meta-analysis. Cureus. 2024; Published.

Abstracts with Poster or Oral Presentation:

  1. Bahar AR, Alrayyashi M, Bahar Y, Alraies MC. Outcomes of lower limb amputation in patients with coronary artery disease. J Am Coll Cardiol. 2024;84(18_Supplement):B273-B274.
  2. Majagi A, Mathur K, Kelly T. Endoscopic through-the-scope tack and suturing for closure of delayed-onset colocutaneous fistula following complicated surgical resection for descending colon malignancy. Gastrointest Endosc. 2024;99(6 Supplement):AB80.
  3. Rutila N, Anjum S, Huang J, Poowuttikul P. Discovering GATA2 deficiency in a case of disseminated mycobacterial infection masquerading as sarcoidosis. ACAAI 2024 Annual Scientific Meeting; October 24-28, 2024; Boston, MA.
  4. Fatima A, Imran N, Yaseen O, Alrawi O. Salt-losing nephropathy associated with supraventricular arrhythmia [Poster Presentation]. American Society of Onconephrology Symposium 2023; October 6, 2023; Houston, TX.
  5. Shatila M, Lu L, Abdul-Baki K, et al. S1301 The impact of metformin use on the incidence and severity of immune-mediated colitis. Am J Gastroenterol. 2024;119(10S):S930-S931.
  6. Fatima A, Almujarkesh MK, Damughatla A, Imran N, Osman-Malik Y. Chemotoxic conundrum: Unraveling a rare nephrotoxic enigma from ifosfamide and carboplatin combination therapy [Poster Presentation]. American Society of Onconephrology Symposium 2023; October 6, 2023; Houston, TX.
  7. Bahar AR, Alrayyashi M, Ziaullah A, Bahar Y, Alraies MC. Endovascular interventions in patients hospitalized with acute ischemic stroke. J Am Coll Cardiol. 2024;84(18_Supplement):B27-B73.
  8. Majagi A, Almujarkesh M, Carter K, Picardal A, Kapur S, Levine D, Lohia P. Hepatitis C: Everything a primary care physician needs to know from diagnosis to long-term follow-up. J Gen Intern Med. 2024;39(2 Supplement):S609.
  9. Shatila M, Rivera A, Abdul-Baki K, et al. S1271 A retrospective study of treatment options for checkpoint-inhibitor colitis and their impact on disease outcomes. Am J Gastroenterol. 2024;119(10S):S905-S906.
  10. Majagi A, Ramaseshan K, Ahmad S, Le T, Kagzi A. Procedures group chat: A resident-driven approach to increase procedural competency [Poster Presentation]. Quality Education and Safe Systems Training Regional Conference; April 8, 2024; Detroit, MI. Award: 1st place, Quality Improvement Competition.
  11. Zong Y. Predicting late recurrence in male estrogen receptor-positive breast cancer with clinical treatment score post-5 years: A SEER database analysis of 65,711 cases [Faculty Speaker]. 2nd Global Summit on Breast Cancer; August 20-24, 2024; Kona, Hawaii.
  12. Majagi A, Saini A, Sabbagh H, Bazzy K, Lilley K, Antaki F. Back to bedside: Is there a need for resident education for inpatient paracentesis? [Poster Presentation]. Quality Education and Safe Systems Training Regional Conference; April 8, 2024; Detroit, MI.
  13. Sharma A, Sharma A, Singh V. Epidemiology, outcomes, and 30-day readmissions in acquired hemophilia. Blood. 2023; Published August 2023. doi:10.1182/blood-2023-191186.
  14. Majagi A, Ramaseshan K, Ahmad S, Polina A, Kagzi A. The push for POCUS: Is there an interest in ultrasound training within a large internal medicine residency program? [Oral Presentation]. 21st Annual University of Southern California Innovations in Medical Education Conference; February 15, 2024.
  15. Shatila M, Cruz CC, Rivera A, et al. S1435 Mystery diarrhea: A comparative analysis of immune-mediated colitis characteristics among patients with and without signs of inflammation on initial work-up. Am J Gastroenterol. 2024;119(10S):S1030-S1031.
  16. Majagi A, Ramaseshan K, Ahmad S, Polina A, Kagzi A. The push for POCUS: Is there an interest in ultrasound training within a large internal medicine residency program? [Poster Presentation]. 5th Annual Medical Education Research and Innovation Conference; November 16, 2023; Detroit, MI. Award: 1st place, Best in Class Research Poster.
  17. Sharma A, Majagi A, Morkos P, Shapoo M, Wadehra A, Mohamad B. Demographics and outcomes of acute liver failure with liver transplantation in the United States. Am J Gastroenterol. 2024; Accepted/In-Press.
  18. Majagi A, Mohiuddin A, Khadra M, Wilson T, Tariq T, Mohamad B. ACEi-ing it! Discovering a rare case of lisinopril-induced pancreatitis. Am J Gastroenterol. 2023;118(10S):S1430-S1431.
  19. Sharma A, Sharma A, Mishra T, Levine D. Causes of non-COVID-19 hospitalization in the United States in 2019 and 2020. [Oral Presentation]. American College of Physicians Michigan Chapter Annual Meeting 2024. Accepted/In-Press.
  20. Gaynier A, Sharma A, Levine D. Preparing medical students for their next evaluation system: Milestone 2.0 self-assessment in a transition-to-residency course. [Presentation]. The Central Group on Education Affairs Spring Conference 2024. Accepted.
  21. Sharma A, Sharma A, Mishra T, Singh V. Impact of COVID-19 pandemic on sickle cell disease. [Presentation]. Michigan Society of Hematology and Oncology Annual Meeting 2023. Accepted/In-Press.
  22. Wu Y, Pegram MD, Kuo W, Chou H, Huang Y, Chen J, Han H, Zong Y, Chen C, Chang Y. Enhancing liquid biopsy potential: The impact of the R3CE 3D culture platform. J Clin Oncol. 2024;42(16_Suppl):e15032.
  23. Sharma A, Majagi A, Morkos P, Shapoo M, Wadehra A, Mohamad B. Demographics and outcomes of acute liver failure with liver transplantation in the United States [Poster Presentation]. American College of Gastroenterology Annual Meeting 2024. Accepted/In-Press. Award: Outstanding Poster Presentation.
  24. Chi J, Aoun H, Chen W, Zong Y, Ristic G, Jang H, Simon MS, Assad H. Percutaneous cryoablation of breast cancer metastases: Analysis of long-term single-center experience, efficacy, and outcomes. J Clin Oncol. 2024;42(16_Suppl):e13105.
  25. Wang FH, Ren F, Qian J, Xu YX, Wu JY, Zong Y, Gu XD. Using the CTS5 score to predict late recurrence in male and female estrogen receptor-positive breast cancer patients: A SEER database analysis of 65,729 cases. Cancer Res. 2024;84(9_Suppl):PO1-08-05.
  26. Shatila M, Rivera A, Gupta T, et al. S1303 Initial histologic presentations of immune checkpoint inhibitor colitis and their differential disease outcomes. Am J Gastroenterol. 2024;119(10S):S932-S933.

ACP Michigan Chapter:

  1. Sharma P, Alrayyashi M, Kadem M, Bahar AR, Arora AK. A case of Ibrutinib withdrawal in a patient with CLL [Poster Presentation]. American College of Physicians Michigan Chapter Annual Meeting 2024. Accepted/Presented as poster.
  2. Arora AK, Alrayyashi M, Zacili A, Huizenga K, Bahar AR. A rare case of disseminated Mycobacterium abscessus causing polyarthritis [Poster Presentation]. American College of Physicians Michigan Chapter Annual Meeting 2024. Accepted/Presented as poster.
  3. Alrayyashi M, Bahar AR, Kaur AK, Sharma P. Inferior vena cava syndrome with dyspnea and edema in a patient with metastatic esophageal adenocarcinoma [Poster Presentation]. American College of Physicians Michigan Chapter Annual Meeting 2024. Accepted/Presented as poster.
  4. Ziaullah A, Le T, Dayco J, Cardozo S. Myocardial infarction due to paradoxical embolism in Fontan circulation: Case report [Poster Presentation]. American College of Physicians Michigan Chapter Annual Meeting 2024. Accepted/Presented as poster.
  5. Fatima A, Polina A, Jean Z, Elbashir M. Not your average monkeypox lesion: A case of superimposed polymicrobial genital wound infection in an HIV patient [Poster Presentation]. American College of Physicians Michigan Chapter Residents and Medical Students Day 2023; May 12, 2023; Troy, MI.
  6. Zaiem F, Sharma A, Ayoub M, Halboni A, Polina A, Kagzi A. Ideal retention time for point-of-care ultrasound education among internal medicine residents [Poster Presentation]. American College of Physicians Michigan Chapter Annual Meeting 2023. Accepted/In-Press.
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